Symbol
Name
ID

Ret
ret proto-oncogene
MGI:97902

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cerebral hemorrhage	Aganglionic megacolon	Pheochromocytoma	Ganglioneuroma	Polydipsia	Intellectual disability	Headache	Global developmental delay
Disease(s) Associated with RET	Cerebral hemorrhage	Aganglionic megacolon	Pheochromocytoma	Ganglioneuroma	Polydipsia	Intellectual disability	Headache	Global developmental delay
Hirschsprung's disease
multiple endocrine neoplasia type 2A
multiple endocrine neoplasia type 2B
pheochromocytoma
renal hypoplasia

Mouse Phenotypes

nervous system phenotype

increased neuron apoptosis

abnormal neuron differentiation

abnormal enteric neural crest cell morphology

adrenergic chromaffin cell hyperplasia

abnormal muscle spindle morphology

increased ganglioneuroma incidence

abnormal enteric nervous system morphology

abnormal enteric ganglia morphology

abnormal enteric neuron morphology

absent enteric neurons

abnormal cardiac ganglion morphology

abnormal pterygopalatine ganglion morphology

abnormal parasympathetic postganglionic fiber morphology

abnormal sympathetic ganglion morphology

abnormal stellate ganglion morphology

absent superior cervical ganglion

small superior cervical ganglion

abnormal prevertebral ganglion morphology

abnormal sympathetic neuron morphology

abnormal sympathetic postganglionic fiber morphology

abnormal hypoglossal nucleus morphology

abnormal facial motor nucleus morphology

abnormal innervation

abnormal innervation pattern to muscle

abnormal motor neuron innervation pattern

abnormal neuron morphology

loss of dopaminergic neurons

decreased motor neuron number

abnormal neuromuscular synapse morphology

small dorsal root ganglion

abnormal neurotransmitter secretion

abnormal synaptic dopamine release

Availability

Mouse Genotype

Ret^tm1.1Ddg/Ret^tm1.1Ddg

Ret^tm1.1Kln/Ret^tm1.1Kln

Ret^tm1.2Pern/Ret^tm1.2Pern

Ret^tm1Cos/Ret^tm1Cos

Ret^tm1Cti/Ret^tm1Cti

Ret^tm1Giro/Ret^tm1Giro

Ret^tm1Heno/Ret^tm1Heno

Ret^tm1Jmi/Ret^tm1Jmi

Ret^tm1Mat/Ret^tm1Mat

Ret^tm2.1Cos/Ret^tm2.1Cos

Ret^tm2.1Heno/Ret^tm2.1Heno

Ret^tm3Cos/Ret^tm3Cos

Ret^tm11(RET)Jmi/Ret^tm11(RET)Jmi

Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi

Ret^tm13.1Jmi/Ret^tm13.1Jmi

Ret^tm1Cos/Ret⁺

Ret^tm1Cti/Ret⁺

Ret^tm2.1Cos/Ret⁺

Ret^{tm3.1(RET)Jmi}/Ret⁺

Ret^tm11(RET)Jmi/Ret^tm12(RET)Jmi

Nkx6-2^tm2(cre)Ercs/Nkx6-2⁺
Ret^tm1.1Pern/Ret^tm1.1Pern (conditional)

Ret^tm1Ddg/Ret^tm1Ddg
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Ret^tm1Kln/Ret^tm1Kln
Tg(Nes-cre)1Kln/0 (conditional)

Ret^tm1Kln/Ret^tm1Kln
Slc6a3^tm1(cre)Xz/Slc6a3⁺ (conditional)

Mnx1^tm4(cre)Tmj/Mnx1⁺
Ret^tm2(RET)Heno/Ret^tm2(RET)Heno (conditional)

Ret^tm1Heno/Ret^tm2(RET)Heno
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Ret^tm2(RET)Heno/Ret^tm1Cos
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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